F. prausnitzii有可能调节类蔬菜摄入量与抑郁症之间的联系
Chatpol Samuthpongtorn1, Allison A Chan1, Wenjie Ma1,2
1Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Microbiome
|November 15, 2024
概括
类植物摄入量与抑郁症风险降低有关,可能由肠道细菌 (如Faecalibacterium prausnitzii) 介导. 这表明,针对肠道微生物群的饮食干预措施可能有助于心理健康.
科学领域:
- 微生物组研究的研究.
- 营养精神病学是一种精神病学.
- 肠-大脑轴 肠-大脑轴
背景情况:
- 肠道微生物群对饮食对健康的影响的作用已知,但影响抑郁风险的特定食物微生物相互作用尚不清楚.
- 来自超过32,000名妇女的纵向数据,结合来自副研究的元基因组学和代谢学,被用来调查这种关系.
研究的目的:
- 确定特定的饮食成分和肠道微生物特征,这些特征相互作用影响抑郁风险.
- 探索潜在的机制连接饮食,肠道微生物群和心理健康.
主要方法:
- 从一个大型纵向队列中分析了几十年的饮食和抑郁症数据.
- 来自子研究 (n=207) 和独立验证队列 (n=307) 的便元基因组学和血代谢学.
主要成果:
- 类摄入量与抑郁症风险降低和15种肠道微生物物种的丰度变化有关,特别是Faecalibacterium prausnitzii.
- 在患有抑郁症的人群中观察到F.prausnitzii及其S-adenosyl-L-methionine (SAM) 循环I通路的丰度较低.
- 减少F. prausnitzii的SAM生产可能会降低肠道单胺氧化酶A基因表达的调节,影响血清素和多巴胺合成.
结论:
- 饮食在预防抑郁症方面起着至关重要的作用.
- 肠道微生物组可能通过影响神经递质合成的微生物途径调解类食用对心理健康的影响.
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