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确定甲状腺相关眼科病的疾病活动和葡萄糖皮质类药物反应:使用动态对比增强MRI的初步研究

Hao Hu¹, Xiong-Ying Pu¹, Jiang Zhou¹

¹Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Korean journal of radiology

|November 15, 2024

概括

额外眼肌的动态对比增强型MRI有助于评估甲状腺相关眼病 (TAO) 活性和葡萄糖皮质激素 (GC) 治疗反应. 特定的MRI参数显示出对诊断TAO和预测治疗结果的希望.

科学领域:

眼科医生眼科眼科
放射学放射学是一门学科.
内分泌学在内分泌学.

背景情况:

甲状腺相关的眼科医症 (TAO) 是一种影响眼肌的自身免疫性疾病.
评估TAO活动和治疗反应通常依赖于临床评估和成像.
动态对比增强型MRI (DCE-MRI) 提供了对组织 perfusion 和 permeability 的详细见解.

研究的目的:

评估DCE-MRI外眼肌 (EOMs) 参数在确定TAO活动中的实用性.
评估DCE-MRI在预测葡萄糖皮质体 (GCs) 治疗反应方面的有效性.

主要方法:

预期招募65名TAO患者 (活跃和不活跃组).
使用无模型 (TTP,AUC) 和基于模型 (Ktrans,Kep,Ve) 的参数对 EOM 的 DCE-MRI 分析.
统计分析包括后勤回归和ROC曲线分析,以确定诊断性能.

主要成果:

活跃的TAO患者与不活跃的患者相比,显示出明显不同的DCE-MRI参数 (TTP,AUC,Ktrans,Ve).
DCE-MRI参数 (TTP-min,Ktrans-mean,Kep) 区分了GC响应和不响应的患者.
TTP-平均值和Ve-平均值预测了TAO活性 (AUROC=0.687),而TTP-min和Ktrans-平均值预测了GC反应 (AUROC=0.821).

结论:

EOM 的 DCE-MRI 参数可以帮助TAO 评估.
TTP-平均值和Ve-平均值是TAO活动评估的潜在生物标志物.
TTP-min和Ktrans-mean作为预测TAO中GC治疗反应的生物标志物非常有希望.

关键词:

疾病活动疾病活动动态对比增强增强的动态对比.磁共振成像技术磁共振成像技术甲状腺相关的眼睛疾病.对治疗的反应反应.

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