长期COVID相关的运动不耐受症背后的代谢和生理障碍
Brooks P Leitner1, Phillip Joseph2, Andres Figueroa Quast2
1Yale School of Medicine New Haven Connecticut USA.
Pulmonary circulation
|November 15, 2024
概括
长期COVID患者的氧气提取和运动能力降低,特别是那些初次感染严重的人. 这种运动不耐受性源于有氧和无氧能量的产生受损,酸盐可能作为生物标志物.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 代谢学 代谢学 代谢学
背景情况:
- 长期的COVID与系统氧气提取 (EO2) 的受损有关,这表明线粒体功能障碍.
- 在长期COVID中,SARS-CoV-2初始感染严重程度对EO2和运动能力 (VO2) 的影响尚不清楚.
- 运动期间长期COVID患者的无氧ATP生成尚未评估.
研究的目的:
- 在长期COVID患者中调查SARS-CoV-2初始感染严重程度和运动不耐受性之间的关系.
- 评估在长期COVID中炼期间的有氧和无氧ATP生成.
- 在长期COVID中识别运动不耐受的潜在生物标志物.
主要方法:
- 对47名长期COVID患者进行了侵入性心肺运动测试 (iCPET).
- 在iCPET期间,对26名患者的子组进行了静脉和动脉血液样本的代谢分析.
- 相关性分析被用来将代谢变化与运动能力和氧气提取联系起来.
主要成果:
- 长期COVID患者表现出降低的峰值EO2和峰值VO2,严重程度取决于影响.
- 与轻度感染相比,严重感染史与较低的VO2和EO2峰值相关.
- 代谢分析显示了代谢物消耗和释放的显著变化,在运动过程中增加了因素和酸盐的动脉静脉梯度.
- 峰值VO2与峰值静脉糖酸盐和乳酸盐水平有很强的相关性.
结论:
- 在长期COVID中,运动不耐受与有氧和无氧能量产生受损有关.
- 最初的SARS-CoV-2感染严重程度显著影响长期COVID相关的运动能力.
- 峰值静脉酸盐可能是评估长期COVID患者的运动不耐受性的潜在生物标志物.
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