与代谢功能障碍相关的脂肪肝疾病的预防和治疗指南 (2024版)
Jian-Gao Fan1, Xiao-Yuan Xu2, Rui-Xu Yang1
1Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal of clinical and translational hepatology
|November 15, 2024
概括
中国中国中国中国.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的非酒精性脂肪性肝病 (MAFLD) 是中国最常见的慢性肝病.
- MAFLD通常与酒精性肝病和慢性乙型肝炎同时发生.
- 肥胖,代谢综合征和2型糖尿病的上升率加剧了MAFLD流行病.
研究的目的:
- 更新2018年中国关于预防和治疗MAFLD的指南.
- 为管理MAFLD和与代谢功能障碍相关的脂肪性肝病 (MASLD) 提供全面的建议.
- 确定"与代谢功能障碍相关的脂肪肝疾病"作为首选的英语术语.
主要方法:
- 召集来自中国肝病学学会和中国医学协会的临床专家小组.
- 修订和更新关于MAFLD的国家指南.
- 结合最新的临床证据和专家的共识.
主要成果:
- "关于预防和治疗与代谢功能障碍相关的脂肪肝疾病的指导方针 (2024年版) "已发布.
- 该指南涵盖了MAFLD/MASLD的查,监测,诊断,评估,治疗和随访.
- 它强调了首选的英语术语"与代谢功能障碍相关的脂肪肝疾病" (MAFLD).
结论:
- 更新的指导方针为中国的MAFLD管理提供了一个全面的框架.
- 多学科合作对于有效管理MAFLD和相关心脏代谢障碍至关重要.
- 该指南旨在解决MAFLD和代谢问题的公共卫生危机.
相关概念视频
Overview of Lipid Metabolism
1.0K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.0K
Chronic Pancreatitis II: Collaborative Care
70
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
70
Overview of Fatty Acid Metabolism
30.2K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
30.2K
Diabetes: Management and Pharmacotherapy
236
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
236
Diabetes: Symptoms, Diagnosis, and Complications
508
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
508
Liver Physiology
442
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
442


