通过微波热水法合成酸:物理化学和形态学表征
Ana Elisa Vilicev Italiano1, Ricardo Luis Tranquilin2, Danny Omar Mendoza Marin3
1Department of Dental Materials and Prosthodontics, Araraquara School of Dentistry, Sao Paulo State University (UNESP), São Paulo, São Paulo, Brazil.
International journal of biomaterials
|November 15, 2024
概括
研究人员开发了一种新的微波热水法,用于合成用于骨移植的先进酸生物材料. 这种方法有效地产生酸和酸,这对于牙科植入物手术中骨再生至关重要.
科学领域:
- 生物材料科学 生物材料科学
- 材料化学 材料化学
- 牙科植入物学 牙科植入物学
背景情况:
- 膜骨损失对牙植入成功提出了重大挑战,影响美观和功能恢复.
- 合成生物材料,特别是酸,对于骨移植至关重要,因为它们具有生物相容性和生物活性.
- 需要有效的合成方法来优化酸骨移植替代品的特性.
研究的目的:
- 通过微波热水法 (HTMO) 合成基于酸的生物材料用于骨移植.
- 评估合成生物材料的微观结构和物理化学特性.
- 研究合成和化温度对产生的材料相的影响.
主要方法:
- 酸颗粒通过微波热水法 (HTMO) 在110°C和130°C进行60分钟的合成.
- 合成的材料随后在300°C,500°C和700°C的温度下进行化.
- 描述涉及扫描电子显微镜 (SEM),富里埃变换红外光谱 (FTIR) 和X射线衍射 (XRD).
主要成果:
- 微波HTMO成功生产了含有多个生物相关相的酸材料:酸 (HA),三酸 (β-TCP) 和八酸 (OCP).
- 增加烧温度显著促进了β-TCP阶段的形成和证据.
- 合成方法在产生具有理想物理和化学性质的生物材料方面被证明是有效的.
结论:
- 微波热水法是一种有效的技术,用于生产用于骨移植应用的先进酸生物材料.
- 由此产生的生物材料表现出具有生物学意义的结晶相的有希望的组合,可通过合成和化温度调节.
- 这种优化的生物材料有可能在患有严重骨缺陷的患者中增强骨再生.
相关概念视频
02:00Molecular Models
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
02:30Water: A Bronsted-Lowry Acid and Base
The reaction between a Brønsted-Lowry acid and water is called acid ionization. For example, when hydrogen fluoride dissolves in water and ionizes, protons are transferred from hydrogen fluoride molecules to water molecules, yielding hydronium ions and fluoride ions:
03:05Acid Strength and Molecular Structure
Binary Acids and Bases
In the absence of any leveling effect, the acid strength of binary compounds of hydrogen with nonmetals (A) increases as the H-A bond strength decreases down a group in the periodic table. For group 17, the order of increasing acidity is HF < HCl < HBr < HI. Likewise, for group 16, the order of increasing acid strength is H2O < H2S < H2Se < H2Te. Across a row in the periodic table, the acid strength of binary hydrogen compounds increases with increasing...
In the absence of any leveling effect, the acid strength of binary compounds of hydrogen with nonmetals (A) increases as the H-A bond strength decreases down a group in the periodic table. For group 17, the order of increasing acidity is HF < HCl < HBr < HI. Likewise, for group 16, the order of increasing acid strength is H2O < H2S < H2Se < H2Te. Across a row in the periodic table, the acid strength of binary hydrogen compounds increases with increasing...
01:15Carboxylic Acid Derivatives: Overview
Carboxylic acid derivatives are formed by replacing the hydroxyl group of carboxylic acids with a different functional group. The most common carboxylic acid derivatives are:
01:16Nomenclature of Carboxylic Acid Derivatives: Acid Halides, Esters, and Acid Anhydrides
Naming Acid Halides
The IUPAC and common names of acid halides are derived from the corresponding carboxylic acids, by changing “ic acid” to “yl halide.” For example, as shown below, the IUPAC name ethanoyl chloride is derived from ethanoic acid, and the common name, acetyl chloride, is obtained from acetic acid.
The IUPAC and common names of acid halides are derived from the corresponding carboxylic acids, by changing “ic acid” to “yl halide.” For example, as shown below, the IUPAC name ethanoyl chloride is derived from ethanoic acid, and the common name, acetyl chloride, is obtained from acetic acid.
01:01Acid Halides to Carboxylic Acids: Hydrolysis
Hydrolysis of acid halides is a nucleophilic acyl substitution reaction in which acid halides react with water to give carboxylic acids. The reaction occurs readily and does not require acid or a base catalyst.
As shown below, the mechanism involves a nucleophilic attack by water at the carbonyl carbon to form a tetrahedral intermediate. This is followed by the reformation of the carbon–oxygen π bond along with the departure of a halide ion. A final proton transfer step yields carboxylic acid...
As shown below, the mechanism involves a nucleophilic attack by water at the carbonyl carbon to form a tetrahedral intermediate. This is followed by the reformation of the carbon–oxygen π bond along with the departure of a halide ion. A final proton transfer step yields carboxylic acid...