患有口腔状细胞癌的老年患者的微血管重建 - 太老了没有手术治疗?
Anne Radermacher1, Dominik Horn1,2, Michael Fehrenz1
1Department of Oral and Cranio-Maxillofacial Surgery, Saarland University Medical Center, Homburg, Germany.
Craniomaxillofacial trauma & reconstruction
|November 15, 2024
概括
口腔状细胞癌 (OSCC) 手术对于老年患者来说是安全的. 晚年没有显著影响生理结果或手术并发症,显示出可比的安全性和有效性.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 老年医学 老年医学
背景情况:
- 高龄是口腔状细胞癌 (OSCC) 的主要危险因素.
- 用微血管重建进行的消耗性手术是OSCC的标准.
- 长期全身麻醉在老年OSCC患者的安全性是有争议的.
研究的目的:
- 评估与患者年龄相关的OSCC的瘤和微血管策略的瘤安全性和手术发病率.
- 为了比较老年 (≥70岁) 和年轻 (<70岁) OSCC 患者之间的结果.
主要方法:
- 对345名初级OSCC患者进行瘤切除,部剖析和微血管重建的回顾性队列研究 (2010年9月 - 2017年10月).
- 临床数据的描述性分析,重点关注56名老年患者 (≥70岁) 的术后发病率.
- 使用Kaplan-Meier绘图和Log Rank测试评估的瘤结局.
主要成果:
- 估计的5年总生存率 (OS) 和无病生存率 (DFS) 在年龄组之间没有显著差异 (OS:69.6%与76.7%;DFS:62.9%与78.2%).
- 在多变量分析中,只有疾病的初始阶段对OS产生了显著影响.
- 没有观察到年龄组之间的术后并发症,片损失,手术时间,气管切除术依赖性或住院时间的显著差异.
结论:
- 用部剖析和初级微血管重建的瘤手术是老年OSCC患者的安全有效治疗方法.
- 晚年并不导致术后发病率,住院或片失效的重大不利因素.
- 该程序产生了优秀的瘤结果,与年轻患者相比.
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