环境空气污染与儿童注意力缺陷/多动障碍 (ADHD) 之间的关联:系统性审查和元分析
Shamshad Ahmad1, Naveen K G1, Arun Mani Babu1
1Community and Family Medicine, All India Institute of Medical Sciences, Patna, Patna, IND.
Cureus
|November 15, 2024
概括
产后暴露于PM2.5和NO2等空气污染物与儿童注意力缺陷/多动障碍 (ADHD) 的风险更高有关. 这一系统性审查强调了对空气质量的进一步研究的需要.
科学领域:
- 环境健康 环境健康
- 儿科神经发育 儿童神经发育
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是儿童中普遍存在的神经发育障碍.
- 越来越多的证据表明,环境因素可能会影响ADHD风险.
- 环境空气污染是一种广泛的环境暴露,具有潜在的健康影响.
研究的目的:
- 系统地审查和元分析产后暴露于环境空气污染物和儿童多动性多动症风险之间的联系.
- 综合了关于颗粒物 (PM2.5,PM10) 和二氧化 (NO2) 暴露的观察性研究的证据.
主要方法:
- 观察性研究的系统审查和元分析 (队列,病例控制,横截面).
- 在主要数据库 (PubMed,科学网,Embase,Ovid) 进行全面的文献搜索,更新时间为2024年5月.
- 使用Joanna Briggs Institute (JBI) 工具进行偏差风险评估;使用随机/固定效应模型进行元分析.
主要成果:
- 在PM2.5暴露和ADHD风险增加之间发现了显著的关联 (I2 = 74.2%).
- 在PM10暴露和ADHD风险之间发现了显著的关联,在异常值被删除后异质性减少 (I2 = 34.94%).
- 在NO2暴露和ADHD风险之间发现了显著的关联,异质性较低 (I2 = 0%).
结论:
- 产后暴露于PM2.5,PM10和NO2与儿童患ADHD的风险增加有显著关联.
- 研究结果强调了空气污染对儿童神经发育的潜在影响.
- 需要进一步的大规模,高质量的研究来确认关联并阐明潜在的机制.
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