接种COVID疫苗后非COVID入住ICU:一个多中心研究
Amarja A Havaldar1, Kaladhar Sheshala2, Raman Kumar3
1Critical Care Medicine, St. John's Medical College Hospital, Bengaluru, IND.
Cureus
|November 15, 2024
概括
接种COVID-19疫苗的时间影响了ICU死亡率,在特定年龄组和在接种后42天内患有脑血管疾病的人群中观察到更高的风险.
科学领域:
- 关键护理医学 关键护理医学
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- 在印度的COVID-19疫苗接种活动中,使用了ChAdOx1 nCov-19 (Covishield) 和BBV152 COVID-19 (Covaxin).
- 免疫接种后的不良事件 (AEFI) 被疾病预防控制中心等卫生当局认可.
- 了解疫苗接种和严重疾病之间的时间关系对于患者安全至关重要.
研究的目的:
- 调查COVID-19疫苗接种时间和ICU入院诊断之间的关联.
- 确定疫苗接种时间对ICU死亡率,住院时间和机械通风持续时间的影响.
主要方法:
- 一项回顾性队列研究,涉及175名在印度四个中心的ICU接受治疗的患者.
- 患者接受了COVID-19疫苗的第一剂或第二剂,并因非COVID相关疾病入院.
- 分析对患者进行了分类,根据接种后≤42天或>42天内入院的情况.
主要成果:
- 整体ICU死亡率为24.57%.
- 在接种疫苗后观察到血栓栓塞事件 (ACS,CVA) 和神经肌肉疾病.
- 在接种疫苗后42天内入院的66岁以上和35岁以下的患者中,死亡率较高 (p=0.008).
- 脑血管疾病与显著更高的死亡率相关 (p<0.001).
结论:
- 接种COVID-19疫苗后可能会出现血栓栓塞和神经肌肉事件,需要接受ICU治疗.
- 在42天内接种疫苗的年轻人 (≤35岁) 和老年人 (>66岁) 中,观察到显著增加的ICU死亡风险.
- 脑血管疾病的诊断与ICU环境中的高死亡率相关.
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