血清双S水平与卵巢储备功能的降低有关:单中心研究
Xinlu Zhang1, Yanmei Wu2, Derui Zhang3
1Department of Reproductive Medicine, Jinan Central Hospital Affiliated to Shandong First Medical University Jinan, Shandong, China.
American journal of translational research
|November 15, 2024
概括
血清双S (BPS) 对女性的卵巢储备产生负面影响. 较高的BPS水平与较低的AMH和E2以及较高的FSH相关,表明卵巢功能下降和卵巢储备减少 (DOR) 的潜在风险.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 双A (BPA) 是一种已知的内分泌干扰物,影响女性生殖健康.
- 双S (BPS) 是一种BPA类似物,在人群中越来越多地检测到它.
- 关于BPS对生殖健康的影响的研究有限.
研究的目的:
- 为了研究血清双S (BPS) 水平与生殖年龄妇女的卵巢储备之间的关联.
- 确定BPS是否是减少卵巢储备 (DOR) 的危险因素.
主要方法:
- 对152名处于生育年龄的妇女进行了回顾性研究.
- 使用ELISA对血清BPS的量化.
- 使用抗穆勒尔激素 (AMH),卵泡刺激激素 (FSH) 和雌激素 (E2) 评估卵巢储备.
- 使用线性,物流和限制立方线 (RCS) 模型进行统计分析.
主要成果:
- 血清BPS水平与AMH和E2呈负相关性,与FSH呈正相关性.
- 与非DOR组相比,DOR组女性的血清BPS水平显著更高.
- 在DOR组中,BPS与AMH和E2负相关,与FSH积极相关.
结论:
- 血清BPS被确定为女性卵巢储备功能受损的潜在危险因素.
- 升高的BPS水平可能导致卵巢储备减少 (DOR).
- 需要进一步的研究来阐明BPS对女性生殖的毒性机制.
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