皮下特异性免疫治疗过敏性鼻炎与喘相结合的有效性:一个回顾性分析
Qing Hao1, Zhenghong Chen2, Yiping Yin1
1Department of Pulmonary and Critical Care Medicine, Renmin Hospital, Hubei University of Medicine Shiyan 442000, Hubei, China.
American journal of translational research
|November 15, 2024
概括
皮下特定免疫疗法 (SCIT) 通过改善症状和肺功能,有效治疗过敏性鼻炎和喘. 在患有过敏性鼻炎和喘的患者中,SCIT的安全性与舌下免疫疗法 (SLIT) 相当.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏学 过敏学
- 肺部病理学 肺部病理学
背景情况:
- 过敏性鼻炎 (AR) 和喘经常并存,带来复杂的管理挑战.
- 特定免疫疗法是过敏性疾病的关键治疗方式.
研究的目的:
- 为了比较皮下特异性免疫疗法 (SCIT) 与亚舌特异性免疫疗法 (SLIT) 在AR与喘相结合的患者的疗效和安全性.
主要方法:
- 对93名AR和喘患者的回顾性分析.
- 患者被分为SCIT (观察组,n=47) 和SLIT (对照组,n=46) 队列.
- 评估临床反应,肺功能,免疫/炎症标志物和不良反应.
主要成果:
- 与SLIT相比,SCIT显示出更高的临床响应率和总鼻腔症状评分 (TNSS),抑郁焦虑压力评分 (DASS) 和鼻腔过敏症状评分 (NASS) 的更大改善.
- SCIT导致肺功能 (FEV1/FVC,PEF) 的显著改善以及免疫标记物的有利调节 (CD14,IL-33,SPD-1,sIgG4,INF-γ,IL-27).
- 在SCIT和SLIT组之间,不良反应的发生率相似.
结论:
- SCIT是AR与喘结合的有效治疗方法,在减轻症状和改善肺功能方面优于SLIT.
- SCIT显示了有利的安全概况,与SLIT相提并论.
- SCIT为管理复杂的过敏呼吸道疾病提供了有价值的治疗选择.
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