带有鼻的eosinophilic慢性鼻炎的术后复发的风险因素:开发一个预测模型
Li Lin1, Bi Deng2, Chenghong Guo1
1Department of Otolaryngology, The People's Hospital of Yubei District of Chongqing Chongqing 401120, China.
American journal of translational research
|November 15, 2024
概括
鉴定带有鼻息肉 (ECRSwNP) 复发的异敏性慢性鼻炎的危险因素至关重要. 一个新的诺莫格拉姆模型准确地预测了复发,有助于个性化治疗以获得更好的患者结果.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 医学统计 医学统计
背景情况:
- 带有鼻息肉 (ECRSwNP) 的异敏性慢性鼻炎通常在术后复发.
- 预测复发对于有效的患者管理和治疗策略至关重要.
研究的目的:
- 确定手术后ECRSwNP复发的关键风险因素.
- 开发和验证一个用于预测高风险患者的诺姆图模型.
主要方法:
- 这是一项对200名ECRSwNP患者的队列研究.
- 单变量和多变量逻辑回归分析用于预测器识别.
- 使用ROC曲线和MAE开发和验证Nomogram.
主要成果:
- 19.5%的患者在六个月内出现复发.
- 确定的风险因素包括手术前的乙氨基酸百分比,脑内皮质,血清特异性IgE,IL-5和手术后的鼻子环境.
- 诺米图表显示了高的预测准确性 (AUC = 0.989,MAE = 0.026).
结论:
- 个人风险评估对于管理ECRSwNP复发至关重要.
- 开发出来的诺莫格拉姆是临床预后的可靠工具.
- 这有助于定制治疗策略,改善患者的治疗结果.
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