血清IL-22和IL-27水平与糖尿病病患者血管病变之间的相关性
1Department of Laboratory, Shanxi University of Traditional Chinese Medicine Affiliated Hospital Taiyuan 030024, Shanxi, China.
American journal of translational research
|November 15, 2024
概括
血清中白素-22 (IL-22) 和白素-27 (IL-27) 水平升高与糖尿病病 (DN) 患者血管病变严重程度的增加有关. 这些细胞因子可以帮助评估微血管病变和预测患者的预后.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
背景情况:
- 糖尿病病 (DN) 是糖尿病的一个主要并发症,经常导致损伤和心血管事件.
- 血管病是DN的一个关键特征,导致疾病进展和不良结果.
- 介质素-22 (IL-22) 和介质素-27 (IL-27) 是参与炎症和免疫反应的细胞因子,可能在DN病变发生中发挥作用.
研究的目的:
- 调查血清IL-22和IL-27水平与DN患者血管病变的存在和严重程度之间的关联.
- 评估IL-22和IL-27作为微血管病变和DN患者预后生物标志物的潜力.
主要方法:
- 一项回顾性研究比较了104名DN患者与104名健康对照人群,测量了血清IL-22和IL-27水平.
- 在随访期间,DN患者按尿路白蛋白分泌率 (UAER) 分组,并评估主要不良心血管事件 (MACE).
- 使用后勤回归和接收器运行特征 (ROC) 曲线分析来识别风险因素并评估诊断/预测效用.
主要成果:
- 与对照组相比,DN患者的血清IL-22和IL-27水平显著更高,与疾病持续时间和功能障碍和脂质失调的标志物有正相关.
- 血清IL-22和IL-27水平被确定为微血管病变的独立风险因素,除了膜过率和囊素C.
- 在经历MACE的DN患者中观察到较高的IL-22和IL-27水平. 结合检测IL-22和IL-27显示高精度 (AUC>0.9) 评估微血管病变和良好的精度 (AUC>0.7) 预后.
结论:
- 血清IL-22和IL-27水平升高与糖尿病病症的严重程度密切相关.
- 这些细胞因子作为有价值的辅助指标,用于评估微血管病变和预测DN患者的预后.
- 这些发现表明IL-22和IL-27在炎症途径中的潜在作用有助于DN并发症.
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