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脊髓灰质炎:关于如何使国际旅行对脊髓灰质炎安全的背景和观点
Dhanya Dharmapalan1, Thekkekara Jacob John2, Robert Steinglass3
1Apollo Hospitals, CBD Belapur, Navi Mumbai 400614, India.
Therapeutic advances in infectious disease
|November 15, 2024
概括
国际脊髓灰质炎的传播仍然是一个全球性的健康问题. 旅行者可以传播野生或疫苗衍生的脊髓灰质炎病毒,强调需要适当的脊髓灰质炎疫苗接种,特别是可变口服脊髓灰质炎疫苗疗效.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 脊髓灰质炎病毒的国际传播仍然是国际关注的公共卫生紧急情况,野生脊髓灰质炎病毒 (WPV) 流行的情况和全球众多疫苗衍生的脊髓灰质炎病毒 (VDPV) 爆发.
- 旅行者可以作为脊髓灰质炎病毒传播的载体,将WPV或VDPV进口到无脊髓灰质炎地区,这强调了国际旅行和大规模聚会的疫苗接种建议的重要性.
研究的目的:
- 突出国际脊髓灰质炎病毒传播的持续威胁,以及旅行者在传播中的作用.
- 讨论脊髓灰质炎免疫,无症状传播以及不同脊髓灰质炎疫苗的不同疗效的细微差别.
主要方法:
- 全球脊髓灰质炎流行病学的审查,包括特有国家和VDPV爆发监测数据.
- 分析脊髓灰质炎病毒传播动态,包括传播途径和无症状感染在免疫和非免疫个体中的作用.
- 对口服脊髓灰质炎疫苗 (OPV) 和非活化脊髓灰质炎病毒疫苗 (IPV) 在不同地理和经济环境中的疫苗疗效 (VE) 数据的评估.
主要成果:
- 两个国家仍然为WPV流行,而许多国家在2023年和2024年经历了VDPV爆发.
- 免疫力可以防止,但不能防止再感染;无症状的个体,无论是否免疫,都可以传播脊髓灰质炎病毒.
- 口服脊髓灰质炎疫苗 (OPV) 的有效性高度变化,在热带低收入国家很低,而非活化脊髓灰质炎病毒疫苗 (IPV) 在全球范围内表现出卓越和一致的有效性.
结论:
- 旅行者是进口脊髓灰质炎病毒的潜在载体,必须确保适当的免疫接种.
- 脊髓灰质炎疫苗接种战略的有效性必须考虑影响疫苗有效性的地理和社会经济因素.
- 无活化脊髓灰质炎病毒疫苗 (IPV) 在全球范围内提供可靠的保护,无论气候或收入水平如何,使其成为打击国际脊髓灰质炎病毒传播的关键工具.
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