E2F1诱导的自克林IL-6炎症循环介导癌症-免疫交叉,预测T细胞表型切换和治疗反应能力

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A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

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Alf Spitschak1, Prabir Dhar1, Krishna P Singh2

  • 1Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Center, Rostock, Germany.

Frontiers in immunology
|November 15, 2024
PubMed
概括

转录因子E2F1通过诱导IL-6驱动黑色素瘤转移和免疫逃避. 这种E2F1-STAT3/IL-6轴创造了一个免疫抑制的瘤微环境,但它的抑制将免疫力转向抗瘤反应.

关键词:
CD4 +/CD8 + T 细胞 CD4 +/CD8 + T 细胞E2F1-STAT3/IL-6网络中的一个.Th2-Th1轮班的工作时间.癌症转移的转移.免疫调节 免疫调节 免疫调节数学建模的数学建模黑色素瘤的秘密体瘤微环境是一个微环境.

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