相关实验视频

Updated: Jun 7, 2025

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

三级淋巴细胞结构密度与免疫检查点抑制剂在固体瘤中的有效性之间的关联:系统性审查和元分析

Bin Jiang¹, Zhuo Wu¹, Yang Zhang¹

¹Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.

Frontiers in immunology

|November 15, 2024

概括

在接受免疫检查点抑制剂 (ICI) 治疗的癌症患者中,高三级淋巴细胞结构 (TLS) 密度预测了更好的反应和更长的无进展生存期 (PFS). 这一发现强调了TLS作为优化ICI治疗策略的潜在生物标志物.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症治疗癌症治疗

背景情况:

三级淋巴体结构 (TLS) 在抗瘤免疫中至关重要,但它们在免疫检查点抑制剂 (ICI) 疗效中的确切作用尚不清楚.
了解TLS密度和治疗结果之间的关系对于优化癌症免疫疗法至关重要.

结论:

在癌症患者中,TLS密度是ICI治疗反应和生存结果的重要预测生物标志物.
评估TLS密度可以帮助患者选择和治疗决策,甚至在传统耐药瘤中潜在地提高ICI疗效.
这些发现支持将TLS评估纳入针对个性化免疫疗法策略的例行患者评估.

关键词:

在PD1/PDL1中.免疫检查点抑制剂免疫检查点抑制剂免疫疗法免疫疗法固体瘤是一种固体瘤.第三级淋巴状结构 (TLS)

更多相关视频

Predictive Immune Modeling of Solid Tumors

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.