临床中的水凝:最新情况
John R Clegg1,2,3,4, Kolade Adebowale5,6, Zongmin Zhao7,8
1Stephenson School of Biomedical Engineering University of Oklahoma Norman Oklahoma USA.
Bioengineering & translational medicine
|November 15, 2024
概括
水凝技术的近期进步导致临床研究中的新注射和非注射水凝产品. 本综述更新了各种应用的已批准的水凝和正在进行的临床试验.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 临床医学 临床医学
背景情况:
- 自20世纪80年代末以来,水凝已在临床环境中使用.
- 聚合物化学和制造方法的重大进步刺激了新的水凝开发.
- 之前的审查集中在可注射的水凝上;这项工作扩大了范围.
研究的目的:
- 提供临床应用中水凝进步的最新概述.
- 在审查中包括可注射和不可注射的水凝.
- 要突出最近批准的水凝产品和正在进行的临床试验.
主要方法:
- 审查最近发表的文献和临床试验数据库.
- 已批准的水凝产品的分析.
- 对局部和可植入水凝的活跃临床试验的讨论.
主要成果:
- 识别已经达到临床研究的新型水凝产品.
- 关于可注射水凝的临床试验现状的总结.
- 现有临床试验的概述,涉及局部和可植入的水凝.
结论:
- 临床水凝领域继续迅速发展,具有多样化的应用.
- 可注射和不可注射的水凝在正在进行的临床研究中显示出显著的前景.
- 持续的研发对于将水凝创新转化为广泛的临床应用至关重要.
相关概念视频
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Water freezes when the intermolecular forces are greater than the kinetic energy. Unlike most other substances, water is less dense in its solid state than in its liquid state. This is because each water molecule can form...
Water freezes when the intermolecular forces are greater than the kinetic energy. Unlike most other substances, water is less dense in its solid state than in its liquid state. This is because each water molecule can form...
Regulation of Water Intake
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Disorder of Water Balance
Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
Quality of Water
In concrete preparation, the quality of water is paramount as it affects the strength and durability of the concrete. Potable water is usually preferred; however, it must not have excessive sodium or potassium to prevent compromising the concrete's integrity. Water quality is typically evaluated based on impurities such as dissolved solids, chlorides, and sulfates, and its pH value is ideally between 6 and 8. Even slightly acidic natural water may be acceptable unless it contains harmful...
Testing Water Quality
When the quality of water for concrete preparation is uncertain, its impact on the setting time of cement and compressive strength of mortar is assessed by comparison with de-ionized or distilled water benchmarks. American Society for Testing and Materials (ASTM) C1602 requires the setting times to be within 90 minutes of the control, British Standard (BS) 3146:1980 allows a 30-minute variance in the initial setting, while British Standards European Norm (BS EN) 1008 specifies initial setting...
Drying Shrinkage
When hardened concrete is exposed to air with a relative humidity of less than 100 percent, it begins to lose the free water within its capillaries. As this water evaporates, the water initially adsorbed onto the calcium silicate hydrates migrates towards these now empty spaces and eventually evaporates as well. Over time, as more water leaves, the volume of the concrete decreases, a phenomenon known as drying shrinkage.
A portion of this drying shrinkage can be reversed; if the concrete is...
A portion of this drying shrinkage can be reversed; if the concrete is...


