前额叶皮质,但不是中间叶,与艾滋病毒感染中年人的情节性记忆有关
Laura M Campbell1, Christine Fennema-Notestine1, Erin E Sundermann1
1University of California San Diego, La Jolla, CA, USA.
Journal of the International Neuropsychological Society : JINS
|November 15, 2024
概括
在艾滋病毒感染者中,前脑结构,而不是阿尔茨海默病的病理,与情节性记忆有关. 在这个中年人群中,随着时间的推移,记忆通常保持稳定.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 神经成像是一种神经成像.
背景情况:
- 在艾滋病毒感染者 (PWH) 和阿尔茨海默病 (AD) 患者中区分记忆缺陷是具有挑战性的,因为症状重叠.
- 与艾滋病毒相关的神经认知障碍 (HAND) 和缓解性轻度认知障碍 (aMCI) 具有相同的记忆障碍特征.
- 识别记忆可能有助于区分HAND和aMCI.
研究的目的:
- 调查PWH.中明显的记忆缺陷 (回忆与识别) 的神经成像相关性.
- 在PWH中检查记忆性能的纵向变化.
- 探索中年PWH大脑结构和记忆衰退之间的关系.
主要方法:
- 结构性MRI和纵向神经心理测试对92名PWH (45-68岁) 进行了测试.
- 线性和逻辑回归分析了记忆表现的基线神经解剖学相关性.
- 多层次建模检查了记忆衰退的神经解剖学预测因素,平均为6.5年.
主要成果:
- 较薄的骨干部与基线认知障碍和更糟糕的延迟回忆有关.
- 更糟糕的延迟回忆也与较薄的正面角中额叶皮层有关.
- 没有发现记忆表现和中间叶或基底腺结构之间的显著关联.
- 认知障碍显示出变化,而延迟回忆仍然相对稳定.
- 基线中部叶和前额结构没有预测记忆力下降.
结论:
- 中年PWH的插曲性记忆主要与前额结构有关.
- 中间叶和前额结构没有预测纵向记忆力下降.
- 记忆仍然相对稳定,这表明前额结构是关键,而不是早期的AD病理,在这个队列.
- 需要进一步的研究来确定识别缺陷是否可以在临床上区分aMCI和HAND.
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