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感知嗅觉功能障碍与中国成年人全因死亡率之间的联系:一项基于社区的前性研究
Zhicheng Zhang1, Yesong Liu2, Yaqi Li3
1School of Public Health, Institute of Nutrition, Zhongshan Hospital, Fudan University, Shanghai, China.
Journal of global health
|November 15, 2024
概括
感知到的嗅觉功能障碍,或减少嗅觉,与中国成年人因任何原因死亡的风险更高有关. 这一发现强调了嗅觉对整体健康和寿命的重要性.
科学领域:
- 老年学是指老年学的学科.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 嗅觉功能障碍越来越被认为是健康状况的潜在指标.
- 以前的研究表明,嗅觉受损与全因死亡率增加之间存在联系.
- 然而,需要进行大规模研究来证实这一关联.
研究的目的:
- 调查中国大型队列中感知到的嗅觉功能障碍和全因死亡率之间的关联.
- 量化与嗅觉功能障碍相关的死亡风险,调整潜在的混因素.
主要方法:
- 利用了卡伊卢安队伍中97,327名中国成年人的数据.
- 在基线通过主观问题评估感知到的嗅觉功能障碍.
- 从政府记录中收集死亡率数据,平均随访时间为6.4年.
- 采用Cox比例危险回归模型来分析死亡风险.
主要成果:
- 在随访期间,共记录了3903例死亡.
- 报告嗅觉功能障碍的个体具有显著更高的全因死亡风险 (调整后的危险比率=1.42;95%信心区间=1.02-2.00).
- 敏感性分析,不包括各种子组,始终支持主要发现.
结论:
- 感知嗅觉功能障碍与中国成年人全因死亡风险增加有关.
- 限制包括缺乏全国代表性样本和主观暴露评估.
- 建议使用客观措施进行进一步的研究,以验证这些发现并探索潜在的机制.
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