副脑膜肌肉肉瘤:欧洲儿科软组织肉瘤研究小组的结果 RMS 2005 研究研究
Reineke A Schoot1, Pieter Taselaar1, Giovanni Scarzello2
1Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Head & neck
|November 15, 2024
概括
在儿童中治疗帕门宁基性狂宫肌肉瘤 (RMS) 并没有改善生存结果. 脑膜干扰,瘤部位和年龄仍然是儿科狂肌肉瘤的关键预后因素.
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症研究 癌症研究
- 肉瘤治疗方法 肉瘤治疗方法
背景情况:
- 副膜性 (PM) 拉布多米索尔科马 (RMS) 与预后不佳有关.
- 之前的研究表明,PM RMS的不良结果.
- 风险分层对于管理PM RMS至关重要.
研究的目的:
- 描述PM RMS的儿科患者的治疗和结果.
- 调查PM RMS风险因素的预后价值.
- 评估PMRMS中风险适应的多模式治疗的有效性.
主要方法:
- 患有PM RMS的患者被纳入欧洲儿科软组织肉瘤研究小组 (EpSSG) RMS 2005研究.
- 治疗涉及风险适应的多模式治疗方法.
- 根据原始地点和最高风险扩展,PM地点得分.
主要成果:
- 这项研究包括381名患有PM RMS的患者.
- 359名患者 (77人接受了手术) 接受了放射治疗.
- 五年无事件生存率为60%,整体生存率为65%.
结论:
- 与历史数据相比,PM RMS患者的结局没有得到改善.
- 严格的放射治疗应用 (94%) 并没有提高存活率.
- 脑膜干扰,PM部位和诊断时的年龄是显著的预后因素.
相关概念视频
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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
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