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从英国的一名患者中分离出一种耐青素的B型链球菌病例
E McGuire1, D Ready2,3, N Ellaby1,4
1Healthcare-Associated Infection (HCAI), Fungal, Antimicrobial Resistance (AMR), Antimicrobial Use (AMU), and Sepsis Division, United Kingdom Health Security Agency (UKHSA), London, UK.
The Journal of antimicrobial chemotherapy
|November 15, 2024
概括
在英国,首个抗青素B型链球菌 (GBS) 隔离物在患有假肢关节感染的患者身上被发现. 这种GBS菌株由于青素结合蛋白基因突变而表现出耐药性,可能是由于长期暴露于抗生素.
科学领域:
- 医学微生物学 医学微生物学
- 基因组流行病学 基因组流行病学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 乙组链球菌 (GBS) 通常对青素敏感.
- 在全球范围内已经出现了对青素耐药性GBS (PRGBS) 的先前报告,但此前在英国没有出现.
- 长期的抗微生物治疗可以推动抗药性发展.
研究的目的:
- 描述英国首次发现的PRGBS隔离体.
- 为了研究这种隔离物中青素耐药性的遗传基础.
- 为了将这种分离物与英国其他流通的GBS菌株进行比较.
主要方法:
- 对七种抗生素的抗生素敏感性进行渐变条纹测试.
- 用于MLST,囊类型和pbp基因突变分析的Illumina短读测序 (HiSeq 2500).
- 基因组与34个同时代英国GBS分离物的基因组比较.
主要成果:
- 该GBS分离物 (囊型Ia,MLST 144) 呈现出青素耐药性 (MIC = 1 mg/L) 和四环素耐药性.
- 对线索利德,红色素,克林达米辛,提科普拉宁和万科米辛的敏感性保持不变.
- 确定了PBP2x和PBP2b中的替代物,以及pbp1a,pbp2a,pbp2x和pbp2b中的变异.
结论:
- 这项研究证实了对PRGBS分离物的首次鉴定,该分离物被提交给英国国家参考实验室.
- 鉴定到pbp基因中的替代表明,由于长时间使用β-lactam抗生素,产生了耐药性.
- 这一发现凸显了英国GBS青素耐药性的潜在出现.
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