在先天性上腺增生症中划分精神病态病态谱:基于人口的注册研究
Marie Lind-Holst1, Dorte Hansen1,2, Katharina Maria Main3,4
1Department of Pediatrics, Hans Christian Andersen Children's Hospital, Odense University Hospital, Kløvervænget 23C, 5000 Odense C, Denmark.
The Journal of clinical endocrinology and metabolism
|November 15, 2024
概括
先天性上腺增生症 (CAH),特别是21-基酶缺乏症 (21-OHD),与患者患精神疾病和自杀行为的更高率有关. 对21-OHD的个人来说,提高对心理健康的认识至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 临床观察表明,先天性上腺增生 (CAH) 与精神健康受损之间存在联系.
- 了解CAH中精神病发病率的程度对于患者护理至关重要.
研究的目的:
- 为了调查精神病诊断和药物使用在全国队列的患者CAH.
- 量化21-基酶缺陷 (21-OHD) 与精神疾病之间的关联.
主要方法:
- 丹麦一项全国性的基于登记册的队列研究.
- 包括所有精神病诊断 (1977-2018) 和药物数据 (1995-2018) 的数据.
- 448名CAH患者 (410名21名OHD) 与44527名匹配的一般人群对照进行了比较.
主要成果:
- 21-OHD患者的精神病诊断风险显著增加 (女性:IRR=2.32,男性:IRR=2.74) 和精神病药物使用 (女性:HR=1.74,男性:HR=1.74).
- 在21-OHD的两性中都观察到酒精使用,压力/调整障碍和自杀行为的风险增加.
- 罕见的CAH形式仅在男性中增加了精神病诊断风险 (IRR=12.85),没有显著的药物风险增加.
结论:
- 21-基酶缺乏与精神病发病率大幅增加有关.
- 医疗保健提供者应保持对被诊断为21-OHD的患者心理健康问题的高度认识.
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