炎症性肠病中的血管内皮生长因子:系统性审查和元分析
Stefano Zoroddu1, Biagio Di Lorenzo1,2, Panagiotis Paliogiannis3,4
1Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
European journal of clinical investigation
|November 15, 2024
概括
血管内皮生长因子 (VEGF) 水平在炎症性肠病 (IBD) 患者中较高,但不是疾病活性的可靠指标. 根据IBD类型,样本类型和地区,VEGF度有所不同.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 生物标志物研究 生物标志物研究
背景情况:
- 血管内皮生长因子 (VEGF) 与炎症和血管生成有关.
- VEGF可能在炎症性肠病 (IBD) 的发病过程中发挥作用,包括克罗恩病 (CD) 和性结肠炎 (UC).
研究的目的:
- 系统地审查和对IBD患者循环VEGF度进行元分析,与健康对照对比.
- 研究IBD类型,样本类型和地理位置对VEGF水平的影响.
主要方法:
- 系统搜索18项涉及1741名IBD患者和1291名对照者的研究.
- 使用标准化平均差异 (SMD) 和95%置信区间 (CI) 的元分析.
主要成果:
- 在IBD患者中,VEGF度显著升高 (SMD = 0.71).
- 性结肠炎患者表现出比克罗恩病患者更高的VEGF.
- 在西欧和亚洲的血清样本和研究中发现了VEGF的升高,但在血或东欧研究中没有发现.
- 在活跃和不活跃的疾病状态之间没有观察到VEGF水平的显著差异.
结论:
- 循环VEGF度在IBD患者中较高,根据疾病亚型,样本类型和地理区域有显著差异.
- VEGF不是评估IBD疾病活动的可靠生物标志物.
- 建议对方法的标准化和对区域因素的进一步研究,以提高VEGF在IBD中的临床效用.
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