微聚焦超声波与可视化诱导皮肤内原蛋白和弹性质的重塑
Kay Marquardt1, Christian Hartmann1, Flora Wegener1
1R&D Skin Lab & Nonclinical Science Department, Merz Aesthetics GmbH, Frankfurt am Main, Germany.
Journal of cosmetic dermatology
|November 15, 2024
概括
微聚焦超声波与实时可视化 (MFU-V) 治疗通过创建热凝结点 (TCP) 来刺激皮肤再生. 这一过程不仅增强了原蛋白,而且还促进了新的弹性纤维的生长,增强了皮肤的弹性和提升.
科学领域:
- 审美学 在审美学方面
- 皮肤病学 皮肤病学
- 再生医学是一种再生医学.
背景情况:
- 微聚焦超声波与实时可视化 (MFU-V) 是一种非侵入性的皮肤提升技术.
- 它针对皮肤和皮下组织,诱导热凝结点 (TCP).
- 这些TCP启动新结合形成和细胞外矩阵重塑以提升皮肤.
研究的目的:
- 为了研究由MFU-V诱导的TCP的组织学进展.
- 为了解MFU-V的潜在作用模式和再生效应提供洞察力.
- 阐明MFU-V在原和弹性质再生中的作用.
主要方法:
- 在标准的三重深度MFU-V治疗后,获得了体内皮肤样本.
- 组织学和免疫组织化学被用来评估TCPs,热冲击蛋白47 (HSP47) 和弹性质表达.
- 评估的重点是细胞和矩阵组件的时间依赖性变化.
主要成果:
- 在特定的深度上,MFU-V用变质原蛋白创建了不同的TCP.
- 到第90天,纤维细胞和成熟的原蛋白显著增加.
- 在TCP区域观察到HSP47阳性纤维细胞的招募和弹性质合成的增加.
结论:
- 通过MFU-V治疗,可以发现弹性纤维刺激和再生的组织学证据.
- 这项技术触发了包括原变性,炎症和重塑在内的愈合级联.
- MFU-V诱导新原和弹性质新生,有助于皮肤提升和提高弹性.
相关概念视频
Renewal of Skin Epidermal Stem Cells
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Tissue Renewal without Stem Cells
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...


