[医院性鼻炎的病因特征]
A I Kryukov1,2, A V Gurov1,2, D S Cherkasov1,3
1Pirogov Russian National Research Medical University, Moscow, Russia.
Vestnik otorinolaringologii
|November 15, 2024
概括
鼻腔膜炎通常是由多药耐药细菌引起的,例如Klebsiella pneumoniae和Acinetobacter baumannii. 个性化治疗调整经验性抗生素治疗对于有效的患者结果至关重要.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 医院流行病学 医院流行病学
背景情况:
- 鼻腔鼻炎是与医疗保健相关的重要感染,特别是在重症监护病房 (ICU).
- 了解病因因子及其抗菌素耐药性模式对于有效管理至关重要.
研究的目的:
- 评估病房性鼻炎的致病原体的定性和定量组成.
- 在当前的临床环境中,评估这些微生物对抗菌化疗药物的敏感性.
主要方法:
- 从2022-2023年进行了一项研究,涉及56名在多学科和传染病医院重症监护室诊断出患有医院性鼻炎的患者.
- 使用定性和定量方法分析了上鼻腔排泄中的微生物组成.
主要成果:
- 在这两种医院类型中,常见的细菌包括Klebsiella pneumoniae,Acinetobacter baumannii和Pseudomonas aeruginosa.
- 观察到高水平的多药性耐药性,89%的多学科医院和91%的传染病医院的菌株表现出耐药性.
- 菌 (Candida albicans) 是唯一被发现的真菌物种,比细菌更少发生.
结论:
- 临床鼻炎的经验性抗生素治疗需要根据个体细菌学发现进行调整.
- 用菌体制剂进行个性化生物疗法可以被视为抗菌化疗的辅助,以增强抗菌作用.
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