Ligilactobacillus salivarius Li01和皮的协同作用可以防止小鼠患上洛佩拉胺诱导的便秘
Lvwan Xu1,2,3, Bo Qiu1, Furong Ba1
1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou 310003, China. mingfei@zju.edu.cn.
这项研究表明,结合益生菌Ligilactobacillus salivarius Li01和皮 (PSH) 有效地治疗小鼠的便秘. 组合改善了肠道通道和便质量,比单独使用任何一种成分都要多.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 便秘是一种常见的胃肠道疾病,影响身体和精神健康.
- 利吉拉克托巴塞勒沙利瓦里乌斯Li01 (Li01) 是一种具有潜在抗便秘作用的益生菌.
- 皮 (PSH) 是一种以其保持水分和滑性质而闻名的食纤维.
研究的目的:
- 为了研究Li01和PSH对小鼠洛佩拉胺诱导的便秘的协同作用.
- 评估联合Li01和PSH治疗对胃肠道通行,便性质和血清GI激素的影响.
- 探索潜在的机制,包括短链脂肪酸和胆酸概况.
主要方法:
- 洛佩拉胺诱导的小鼠便秘模型.
- 使用Li01,PSH或两者的组合.
- 评估胃肠道过渡速率和便中的水含量.
- 测量血清中胃肠道激素水平.
- 对胃肠道中短链脂肪酸和胆汁酸的分析.
- 通过Li01.01进行PSH的体外发酵.
主要成果:
- 与单个处理相比,联合Li01和PSH处理显著改善了肠道肠道过渡率,增加了便中的水含量.
- 组合疗法有效调节了肠道激素的血清度.
- 在接受联合治疗的小鼠的肠道中观察到高水平的黄油酸和更高比例的非12-OH胆酸.
- 在实验室中,Li01显示出产生黄油酸和发酵PSH的能力.
- 没有观察到肠道微生物群组成的显著变化,这表明这些影响并不依赖于微生物群.
结论:
- 益生菌Li01和益生菌PSH在小鼠模型中表现出对便秘的协同保护作用.
- 这种组合可以通过涉及黄油酸和胆酸代谢的机制来增强胃肠道功能.
- 01和PSH显示出作为有效的功能性食品成分的潜力,用于控制便秘.
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