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在循环吐综合征中对持续疼痛的改变的寄生交感外流和中央敏感反应:功能磁共振成像研究

Andrew Bolender^1,2, Rowan Staley^1,2, Ronald G Garcia^1,3,4

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States.

American journal of physiology. Gastrointestinal and liver physiology

|November 15, 2024

概括

患有周期性吐综合征的患者表现出自主反应和疼痛处理的改变. 他们的大脑表现出不同的连接模式,影响疼痛感知和自主控制.

科学领域:

神经科学是一个神经科学.
胃肠病学胃肠病学
自主神经系统研究自主神经系统研究

背景情况:

循环吐综合征 (CVS) 是一种与自主功能障碍相关的脑肠疾病.
了解CVS需要研究自主反应,疼痛感知和大脑活动之间的相互作用.

研究的目的:

为了检查CVS患者对有害刺激的dysautonomic反应.
在CVS患者中整合自主流出指标,疼痛时间总和和脑功能MRI (fMRI).

主要方法:

从CVS患者和健康成年人获得的依赖血氧水平 (BOLD) fMRI和心电图.
应用了持续的袖口压力疼痛刺激,并评估了疼痛强度和时间总和.
分析了参与自主控制和整体感应的大脑区域的心率变化 (HRV) 和功能连接.

主要成果:

与对照组相比,CVS患者在持续疼痛期间显示高频率HRV降低和大脑连接性改变.
患者报告疼痛强度随着时间的推移而增加,与健康成年人不同.
健康的成年人显示疼痛敏感性和连接性之间的相关性;这些在CVS患者中不存在.

结论:

肺复苏症患者表现出改变了对感觉刺激的中央处理和自主反应能力.
参与自主控制和整感受的关键大脑区域在心血管系统中表现出功能差异.
这些发现突出显示了循环吐综合征中大脑肠道相互作用的改变和自主功能障碍.

关键词:

循环性吐综合征循环性吐综合征整体感受整体感受整体感受神经成像是一种神经成像.疼痛的时间总和.

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