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在纽卡斯尔1000例怀孕队列中采集,处理和储存生物样本的方法:澳大利亚长度,前性基于人口的研究协议

Joshua J Fisher¹, Tegan Grace¹, Nathan A Castles¹

¹School of Medicine and Public Health, College and Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, Australia.

JMIR research protocols

|November 15, 2024

概括

纽卡斯尔1000研究 (NEW1000) 正在创建一个来自孕妇和她们伴侣的生物样本的综合生物库. 该资源将支持对跨代非传染性疾病发育起源的研究.

科学领域:

健康和疾病的发育起源 (DOHaD)
基于人口的怀孕队列研究.
多代性的健康研究.

背景情况:

在最初的1000天内发生的不良事件会影响一生的健康.
将早期生命暴露与以后的健康结果联系在一起的机制需要进一步阐明.
纽卡斯尔1000研究 (NEW1000) 解决了这一知识差距.

研究的目的:

建立一个全面的,前性的怀孕队列研究 (NEW1000).
调查非传染性疾病的发育起源.
提供纵向的,多系统的表型与强大的临床数据和生物样本.

主要方法:

详细描述了对NEW1000生物库的样本采集,储存和实用性的详细描述.
专注于将样本集成到大规模的"omics"平台 (基因组,微生物组,表观基因组等). ) 的情况.
收集母亲,父亲和胎儿的血液,微生物组,尿液,唾液,头发,指甲,胎盘,母乳和母乳.

主要成果:

招聘开始于2021年3月;截至2024年7月,已有1040名妇女和684名伴侣注册,922名婴儿出生.
新1000生物库收藏了大量的样本,包括血,毛皮,血清,尿液,微生物体拭片,唾液,母乳,胎盘,头发和指甲样本.
详细的库存超过24000个血量和广泛的微生物群和尿液样本.

结论:

NEW1000正在产生一个深度表型,多代群体.
全面的生物库支持跨多个"omics"平台的多样化分析.
这种资源对于进一步了解非传染性疾病的发育起源至关重要.

关键词:

这是生物银行协议.血液血液血液血液队列研究是一项队列研究.头发头发头发头发头发微生物组是一个微生物组.怀孕怀孕怀孕怀孕怀孕怀孕队列研究怀孕队列研究脚指甲的指甲是指甲.尿液尿液尿液

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