周围动脉疾病,下肢再血管化和下肢截肢事件中的趋势2型糖尿病:丹麦基于人口的队列研究
Christine Gyldenkerne1,2, Kevin K W Olesen1, Pernille G Thrane1
1Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Diabetes care
|November 15, 2024
概括
周围动脉疾病 (PAD) 和下肢截肢 (LE) 在2型糖尿病患者中显著减少. 尽管情况有所改善,但与普通人群相比,风险仍然较高.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 2型糖尿病是外周动脉疾病 (PAD) 和其严重并发症 (包括下肢截肢) 的主要危险因素.
- 糖尿病患者中PAD,再血管和截肢的趋势对于了解疾病负担和医疗保健需求至关重要.
研究的目的:
- 在被诊断为2型糖尿病的患者中调查PAD,LE再血管化和LE截肢发生率的时间趋势.
- 将这些趋势与一般人群中观察到的趋势进行比较.
主要方法:
- 丹麦的一项全国性队列研究包括1996年至2015年期间被诊断患有2型糖尿病的患者,并一直跟踪至2020年.
- 糖尿病患者的年龄和性别与一般人群中的个人相匹配.
- 该研究使用考克斯回归分析了PAD,5年累积发病率,LE再血管化和LE截肢.
主要成果:
- 从1996-2000年到2011-2015年,糖尿病患者的5年累计PAD发病率从6.2%降至3.4%.
- 在糖尿病队列中,LE重血管化和LE截肢的发生率也显著下降,截肢率从1.0%降至0.4%.
- 虽然糖尿病患者的并发症减少,但其发病率仍然是普通人群的两到三倍,其中的发病率稳定.
结论:
- 近几十年来,患有2型糖尿病的患者下肢并发症的累积发病率大幅下降.
- 尽管出现了显著的改善,但2型糖尿病患者与一般人群相比,仍然面临不成比例地更高的PAD和LE截肢风险.
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