基因与环境的相互作用对母亲教育对青少年神经发育的影响使用ABCD研究
Runye Shi1, Xiao Chang2,3,4,5, Tobias Banaschewski6
1School of Data Science, Fudan University, Shanghai, China.
Science advances
|November 15, 2024
概括
母亲教育通过与基因相互作用,影响青少年大脑发育. 社会经济地位,而不是家庭环境,塑造了这些对大脑结构的遗传影响.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 发展心理学 发展心理学
背景情况:
- 母亲教育与青少年的认知和心理健康结果有关.
- 孕产妇教育对神经发育的影响背后的分子机制尚不清楚.
研究的目的:
- 研究母亲教育和青少年大脑形态之间的基因环境相互作用 (G×E).
- 确定介导这些G×E效应的生物途径和社会因素.
主要方法:
- 使用了青少年大脑认知发展 (ABCD) 队列.
- 进行了全基因组相互作用研究,以确定影响区域灰质量量的G×E位点.
主要成果:
- 确定了7个基因组位点,显示显著的G×E与母亲对大脑结构的教育.
- 丰富的功能包括代谢,炎症和突触可塑性过程.
- 社会经济地位是遗传效应的强烈调节者,而不是家庭环境.
结论:
- 母亲教育通过G×E修改了对青少年神经发育的遗传影响.
- 共享的生物机制将母亲教育的神经发育效应与行为和疾病表型联系起来.
- 社会经济地位是这些影响大脑发育的基因环境相互作用的关键社会决定因素.
相关概念视频
Gene-Environment Interactions
253
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
253
Environmental Influences on Intelligence
214
Despite the strong genetic influence on traits like intelligence, environmental factors significantly shape outcomes. For example, while over 90% of height variation is due to genetic differences, environmental factors such as nutrition also have a notable impact. Similarly, for intelligence, changes in a child's surroundings can significantly alter their IQ. Research shows that enriched environments boost children's academic success and help them develop key cognitive skills. Children...
214
Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
Behavioral Genetics and Its Designs
329
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
329
Biological Influences on Intelligence
74
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
74
Attention-Deficit/Hyperactivity Disorder
44
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
44


