相关实验视频
Updated: Jun 7, 2025

09:51
Cochlear Surface Preparation in the Adult Mouse
Published on: November 6, 2019
15.7K
了解与年龄相关的中耳特性和听力损失中的基底膜损伤:有限元分析和回顾性队列研究
Tzu-Ching Shih1, You-Cheng Yu2, Tang-Chuan Wang3
1Department of Biomedical Imaging and Radiological Science, College of Medicine, China Medical University, Taichung, 404328, Taiwan; The PhD Program for Medical Engineering and Rehabilitation Science, College of Biomedical Engineering, China Medical University, Taichung, 404328, Taiwan.
Computers in biology and medicine
|November 15, 2024
概括
老年人在1.0kHz时表现出导电性听力损失,但在2.0kHz时改善了中耳传输. 老龄化加剧了基底膜损伤从大声的语音频率.
科学领域:
- 听力学 听力学是指听力学.
- 生物医学工程 生物医学工程
- 老年学是一门学科.
背景情况:
- 与年龄相关的听力损失 (ARHL) 经常与内耳问题有关,但中耳的作用不太了解.
- 了解中耳与年龄相关的变化对于诊断和治疗听力损失至关重要.
研究的目的:
- 用有限元模型 (FE) 调查中耳功能中与年龄相关的差异.
- 为了比较年轻和年长的成年人之间的模拟空气-骨隙 (ABGSim) 和基底膜 (BM) 损伤.
主要方法:
- 一项回顾性队列研究分析了来自90名年轻人和111名老年人的临床数据.
- 纯色音频测量 (PTA) 提供了0.5,1.0,2.0和4.0kHz的空气骨间隙 (ABG) 测量.
- 一个有限元 (FE) 模型模拟了带位移 (ABGSim) 和听觉风险单位 (ARU) 用于BM损伤评估.
主要成果:
- 年龄较大的成年人在1.0kHz (P=0.008) 时显示出显著更高的ABGSim,这表明传导性听力损失.
- 在老年人中,在2.0kHz时观察到中耳声音传输效率的适度提升.
- 在高音压水平 (>90 dB SPL) 的话语频率范围 (0.5-4.0 kHz) 内的老年人中发生了明显的BM损伤.
结论:
- 由于中耳的变化,老年人经历了1.0kHz的显著导电性听力损失.
- 衰老对中耳的影响在频率上有所不同,在2.0kHz的传输中有一些增强.
- 高强度的语音频率会加剧与年龄相关的基底膜损伤.
更多相关视频
相关概念视频
The Cochlea
44.5K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
44.5K
The Auditory Ossicles
1.6K
The auditory ossicles of the middle ear transmit sounds from the air as vibrations to the fluid-filled cochlea. The auditory ossicles consist of two malleus (hammer) bones, two incus (anvil) bones, and two stapes (stirrups), one on each side. These bones develop during the fetal stage and are the ones to ossify first. They are fully mature at birth and do not grow afterward.
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
1.6K
Anatomy of the Ear
7.2K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
7.2K
Auditory Pathway
4.9K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
4.9K
Hair Cells
40.1K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
40.1K
Hearing
51.8K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
51.8K

