肠道微生物群通过平衡Th17/Treg细胞来促进肠道和肠外免疫平衡
Jing Wang1, Yaqin Hou1, Lifeng Mu1
1Department of Pharmacy, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China; Department of Pharmacy, North Sichuan Medical College, Nanchong 637000, China.
International immunopharmacology
|November 15, 2024
概括
肠道微生物群通过平衡T辅助细胞17 (Th17) 和调节性T (Treg) 细胞来影响宿主健康. 本综述探讨了肠道微生物和微生物疗法如何影响免疫平衡的平衡.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群通过免疫调节对宿主健康起着至关重要的作用.
- 辅助性T细胞17 (Th17) 和调节性T细胞 (Treg) 是重要的CD4+T细胞子集,对免疫调节至关重要.
- Th17/Treg细胞的不平衡与各种免疫相关疾病有关.
研究的目的:
- 综合审查肠道微生物群对Th17/Treg细胞平衡的调控作用.
- 探索肠道微生物群在维持肠道和肠外免疫平衡中的作用.
- 讨论针对Th17/Treg轴的微生物干预的治疗潜力.
主要方法:
- 对肠道微生物群和T细胞子集现有研究的文献综述.
- 对影响Th17/Treg差异化的微生物物种,成分和代谢物的分析.
- 检查微生物治疗药物,如益生菌,益生菌,后生菌和便微生物群移植 (FMT).
主要成果:
- 肠道微生物群的组成和代谢物显著调节肠道和远部器官 (肺,肝脏,大脑,脏,骨) 中的Th17/Treg细胞平衡.
- 调节的Th17和Treg细胞可以来自本地和全身免疫区.
- 微生物疗法通过调节Th17/Treg轴来证明治疗疾病的潜力.
结论:
- 肠道微生物群对于通过平衡Th17和Treg细胞来维持免疫平衡至关重要.
- 准肠道微生物群为免疫相关疾病提供了有希望的治疗策略.
- 对微生物疗法的进一步研究有临床应用的潜力.
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