Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Necrosis01:16

Necrosis

4.3K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Combined application of Bacillus velezensis JDB15 and Trichoderma harzianum JDL4 suppresses banana Fusarium wilt under controlled conditions.

Pest management science·2026
Same author

Biochemistry at scale: Seeing both the forest and the trees.

Trends in biochemical sciences·2026
Same author

Osteoclast Heterogeneity in Osteoarthritis: From Single-Cell Microenvironments to Program-Specific Therapeutic Opportunities.

International journal of molecular sciences·2026
Same author

Electrophilic monocarbonyl curcumin derivatives reveal differential vulnerabilities in the selenium metabolic network.

Free radical biology & medicine·2026
Same author

An in-depth analysis of the molecular changes induced by short-term calorie restriction before living kidney donation.

npj aging·2026
Same author

Cytosolic PRDX1 acts as an extramitochondrial sink to set mitochondrial H<sub>2</sub>O<sub>2</sub> levels and enable resilience to chronic mitochondrial oxidative stress.

Redox biology·2026

相关实验视频

Updated: Jun 7, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

874

通过指导细胞利用,PRDX6决定了铁灭的敏感性.

Junya Ito1, Toshitaka Nakamura2, Takashi Toyama3

  • 1Institute of Metabolism and Cell Death, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Bavaria 85764, Germany; Laboratory of Food Function Analysis, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi 980-8572, Japan.

Molecular cell
|November 15, 2024
PubMed
概括

氧化素6 (PRDX6) 帮助细胞利用来产生谷氨过氧化酶4 (GPX4),影响铁亡. 它的缺失使癌细胞对铁亡敏感,突出了它在代谢和细胞死亡调节中的作用.

关键词:
在GPX4中使用GPX4.这是LC-MS/MS.大脑大脑大脑的大脑大脑细胞死亡是细胞死亡.半氨酸 (cysteine) 是一种氨酸.脂质过氧化过氧化化是一种化.单半氨酸是一种单半氨酸.单蛋白质是一种单蛋白质.瘤是一个瘤.

更多相关视频

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII
04:48

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII

Published on: May 4, 2020

8.0K
Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
07:32

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

68

相关实验视频

Last Updated: Jun 7, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

874
Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII
04:48

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII

Published on: May 4, 2020

8.0K
Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
07:32

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

68

科学领域:

  • 细胞生物学 细胞生物学
  • 生物化学 生物化学
  • 在瘤学瘤学.

背景情况:

  • 依赖的谷氨过氧化酶4 (GPX4) 通过降低脂氧化物 (PLOOH) 来预防铁亡是至关重要的.
  • 其他脂过氧酶在ferroptosis调节中的作用尚未完全理解.

研究的目的:

  • 调查替代脂过氧化酶在铁灭保护中的贡献.
  • 阐明Peroxiredoxin 6 (PRDX6) 影响铁亡的机制.

主要方法:

  • 基因操纵 (基因淘汰/过度表达) 的PRDX6和GPX4.
  • 测量脂氧化 (PLOOH) 的水平.
  • 评估癌细胞和瘤异种移植中的铁灭敏感性.
  • 对的利用和纳入蛋白的分析.

主要成果:

  • 缺乏GPX4的细胞保留了显著的PLOOH降低能力,这表明了替代机制.
  • PRDX6的遗传损失使癌细胞对铁亡产生敏感,尽管其过度表达并不能防止其发生.
  • PRDX6作为一种受体蛋白,增强了GPX4合成的利用率.
  • 在PRDX6缺陷模型中观察到GPX4表达的减少和铁灭敏感性的增加.

结论:

  • PRDX6在细胞代谢和GPX4依赖性铁亡保护中发挥着关键作用.
  • PRDX6通过影响的融入到必需的蛋白质中,作为铁灭菌敏感性的关键调节剂.