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在小鼠中,neohesperidin通过抑制NF-κB/p65和MAPK通路来保护大肠炎相关的结直肠癌.

Xingyue Cao1, Lingling Li1, Jianing Hu1

  • 1Key Laboratory of Human Genetics and Environmental Medicine, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, China.

The Journal of nutritional biochemistry
|November 15, 2024
PubMed
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在小鼠模型中,Neohesperidin (NHP) 有效地减少了结肠炎和结肠癌. 这种类黄抑制了瘤生长,促进了亡,并减少了炎症,显示了炎症性肠病 (IBD) 和结肠炎相关结肠直肠癌 (CAC) 治疗的前景.

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大肠炎相关的结肠直肠癌.炎症 炎症是一种炎症.这就是MAPKK的意思.在 NF-κBB 中.新esperidin 的使用情况.

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科学领域:

  • 生物化学 生物化学
  • 药理学 药理学是指药理学的学科.
  • 在瘤学瘤学.

背景情况:

  • 炎症性肠病 (IBD) 患者面临着结肠炎相关结肠直肠癌 (CAC) 的风险增加.
  • 新素 (NHP),一种类黄,表现出已知的抗炎,抗氧化和抗癌特性.
  • 在预防结肠瘤发生方面,NHP的特定作用仍然在很大程度上未被描述.

研究的目的:

  • 调查Neohesperidin (NHP) 对结肠炎相关结肠直肠癌 (CAC) 发展的化学预防潜力.
  • 在已建立的CAC体内模型中评估NHP的疗效.

主要方法:

  • 一个阿佐西米 (AOM) /德克斯硫酸 (DSS) 鼠标模型被用于诱导大肠炎和CAC.
  • 在整个实验期间,NHP每天通过口服 gavage 10 周的时间被管理.
  • 评估了炎症,增殖,亡,血管生成和相关信号通路 (NF-κB,MAPK) 的关键标志物.

主要成果:

  • 在AOM/DSS模型中,NHP显著改善了结肠炎症状,并抑制了结肠瘤的形成.
  • NHP治疗减弱了瘤细胞增殖,诱导了亡,并抑制了血管生成.
  • 在剂量取决的方式中,NHP减少了巨细胞的透,并抑制了促炎性细胞因子 (TNF-α,IL-1β,IL-6,COX-2).
  • NHP的疗效高于或与标准治疗剂梅萨拉相当.

结论:

  • 新素 (NHP) 对结肠炎相关的结肠直肠癌 (CAC) 具有显著的化学预防作用.
  • 通过减少炎症,抑制瘤生长和调节关键细胞通路来发挥NHP的作用.
  • NHP代表了一个有希望的治疗候选人,用于管理IBD和预防CAC.