聚焦染色体外圆形DNA (eccDNA) 的功能和趋势:2008年至2023年的文献分析
1Zhuhai Jingyuan Biomedical Technology Co., LTD, Zhuhai, Guangdong, 519000, People's Republic of China.
Experimental cell research
|November 15, 2024
概括
染色体外圆形DNA (eccDNA) 研究正在迅速发展,重点关注其在基因组可塑性和癌症中的作用. 这种图书统计分析绘制了该领域的发展,关键主题和未来的挑战.
科学领域:
- 基因组学就是基因组学.
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- 染色体外圆形DNA (eccDNA) 是在真核生物中发现的核体结构,影响基因组的不稳定性,可塑性,基因表达和进化.
- eccDNA研究已经显著扩大,最近的研究集中在癌症应用上的研究显著增加.
研究的目的:
- 对从2008年到2023年的eccDNA研究进行文献计量分析.
- 绘制eccDNA研究的发展,合作,研究热点和时间趋势的地图.
- 确定当前的挑战,并概述eccDNA的生物特征和功能,特别是癌症.
主要方法:
- 从科学网络核心集合 (2008-2023) 中对242篇出版物的图书统计分析.
- 使用CiteSpace,R包Bibliometrix和VOSviewer进行数据分析.
- 审查了eccDNA的生物特征和功能,强调癌症研究.
主要成果:
- 美国,加利福尼亚大学系统和特纳Km分别被确定为领先的国家,组织和作者.
- 关键的研究热点包括特征和诊断,异色素,Circ-Seq和癌症药物耐药性.
- 该领域呈现快速增长,特别是在与癌症相关的研究中,这表明学术关注度越来越高.
结论:
- 图书统计分析提供了eccDNA研究发展和趋势的全面概述.
- 虽然eccDNA研究正在进步,但需要更清楚地了解其在癌症中的进化模式.
- 这项研究强调了eccDNA日益重要的重要性,特别是在瘤学中,并概述了未来的研究方向.
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