遗传和表观遗传因素影响单胞胎双胞胎中阴道内膜介质厚度
Saho Mori1, Yuya Arakawa2, Mika Hasegawa1
1Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine, Yamadaoka 1-7, Suita, Osaka, Japan.
Gene
|November 15, 2024
概括
研究人员确定了影响双胞胎动脉内心介质厚度 (IMT) 的遗传和表观遗传因素. 这些发现可能有助于个性化的动脉样硬化风险评估.
科学领域:
- 遗传学和表观遗传学
- 心血管研究研究心血管研究
- 双胞胎研究 双胞胎研究
背景情况:
- 动脉内心介质厚度 (IMT) 表明亚临床动脉样硬化,并受到遗传和表观遗传因素的影响.
- 个人IMT的变化是显著的,受糖尿病和免疫反应等疾病的影响.
研究的目的:
- 为了确定特定的单核酸多态 (SNPs) 和影响 carotid IMT 的 DNA 甲基化模式.
- 调查对单胞胎 (MZ) 双胞胎IMT变异的遗传和表观遗传贡献.
主要方法:
- 使用超声波测量IMT在107对MZ双胞胎.
- 采用珠数组用于SNP基因型和甲基化分析,以及用于基因表达的RNA测序.
- 对双胞胎进行了线性回归分析,以评估遗传和表观遗传的影响.
主要成果:
- 确定了与最大和平均IMT相关的显著表观遗传因素 (HS3ST6上的CpG位 cg02432467).
- 在CG07927379的甲基化,LINC01006表达和IMT-Cmax之间发现了负相关性.
- 根据rs10902263多态的基因型,观察到AP2A2表达和平均IMT的显著差异.
结论:
- 发现了与动脉IMT相关的新型遗传和表观遗传因素.
- 这些已识别的因素显示出在动脉样硬化个性化风险评估中使用的潜力.
相关概念视频
Gene-Environment Interactions
253
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
253
Behavioral Genetics and Its Designs
329
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
329
Polygenic Traits
64.8K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
64.8K
Human Genetics
535
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
535
Genomic Imprinting and Inheritance
33.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
33.3K
Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K


