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从海洋海绵Coscinoderma bakusi中分离出来的sesterterpenoids

Huynh Nguyen Khanh Tran¹, Long Hoang To², Soo-Jin Heo³

¹Marine Natural Product Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyangro, Busan, 49111, Republic of Korea.

|November 15, 2024

概括

研究人员从海绵Coscinoderma bakusi中分离出了新的海洋类类植物,扩大了这些天然产品已知的化学多样性. 化合物7对hTRPA1和黄金葡萄球菌表现出中度活性.

科学领域:

海洋天然产品化学化学
有机化学有机化学
化学生态化学生态学

背景情况:

海洋海绵是结构多样化的二次代谢产物的丰富来源.
塞斯特类,C20类的一类,表现出广泛的生物活动.
海绵Coscinoderma bakusi是新型化学实体的潜在来源.

研究的目的:

从Coscinoderma bakusi中分离和表征新的sesterterpenoid衍生物.
为了研究海洋类动物的化学多样性.
评估分离化合物的生物活性.

主要方法:

使用色谱技术分离和净化化合物.
使用核磁共振 (NMR) 光谱和高分辨率质谱法 (HRMS) 阐明结构.
对hTRPA1,细菌菌株,癌细胞系和巨细胞进行生物活性查.

主要成果:

分离出了12种新甲化物衍生物 (1-12) 和2种硫酸盐衍生物 (13-14).
确定了9种新的化合物 (4-9,11,12,14),包括化物A-H和硫酸11.
化合物7显示对hTRPA1 (IC50,34.5μM) 和黄金葡萄球菌 (MIC,32.0μg/mL) 的活性.
硫酸衍生物14在LPS激活的RAW 246.7巨细胞中抑制了NO的产生 (10.0μM时为45%).

结论:

这项研究扩大了已知的海洋类类生物的化学多样性.
化合物11和12具有罕见的类部分.
虽然大多数化合物活性较低,但这些发现有助于理解海洋天然产品的化学成分.

关键词:

科斯基诺德玛巴库西 (Coscinoderma bakusi) 是一种植物.硫酸盐是一种硫酸盐.在MIC中,MIC是MIC,MIC是MIC.没有生产,没有生产.新型化物新型化物这些是海绵科的海绵科.暂时的受体潜在的安基林1 1

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