在Klebsiella pneumoniae中消毒剂耐受性的发展
D J Noel1, C W Keevil1, S A Wilks2
1School of Biological Sciences, University of Southampton, Southampton, UK.
The Journal of hospital infection
|November 15, 2024
概括
临床上相关的Klebsiella pneumoniae可以对常见的消毒剂产生耐受性,适应性增加耐药性高达413%. 消毒剂暴露的顺序对于耐受性发展至关重要,并对感染控制实践产生影响.
科学领域:
- 微生物学 微生物学
- 抗微生物耐药性 抗微生物耐药性
- 感染控制 感染控制
背景情况:
- 消毒剂对于医疗保健,食品生产和家庭环境中的感染控制至关重要.
- 当细菌暴露在生物膜中或通过无效使用时,细菌可以对消毒剂产生耐受性.
- 适应非抗生素抗微生物剂是抗微生物耐药性的一个未被认可的方面.
研究的目的:
- 评估临床相关的Klebsiella pneumoniae对常见消毒剂的适应性.
- 提供有关消毒剂耐受性的见解,作为抗菌素耐药性的一个被忽视的方面.
主要方法:
- 克莱布西埃拉肺炎NDM-1菌株NCTC 13443受到连续通道暴露.
- 对甲化物,二二甲基化物,聚甲比古安化物,甲和甲进行了适应性测试.
主要成果:
- K. pneumoniae对所有测试过的消毒剂都产生了耐受性,最小的抑制度增加了30-413%.
- 观察到交叉耐受性,但适应菌株经常显示出由于健身成本而对第二种消毒剂的敏感性增加.
- 消毒剂耐受性菌株之间的交叉耐受性和附带敏感性并不总是相互的.
结论:
- 消毒剂暴露的顺序显著影响了K. pneumoniae的耐受性发展.
- 这些发现对于优化消毒剂清洁方案具有重要意义.
- 即使在具有相似作用的消毒剂中,潜在的耐受性机制的变化也可能解释观察到的结果.
更多相关视频
相关概念视频
01:30Development of Antibiotic Resistance
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
01:28Antimicrobial Effectiveness
2
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
2
01:31Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K