交叉连接剂在推进基托基生物复合材料支架骨组织工程中的作用:综合性综述
Venkatasubramanian Sai Krishna1, Velan Subashini1, Adithya Hariharan1
1Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India.
International journal of biological macromolecules
|November 15, 2024
概括
交叉连接的奇托桑支架通过提高机械强度和生物相容性来增强骨组织工程. 了解交叉连接器化学是有效的骨再生疗法的关键.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 聚合物化学 聚合物化学
背景情况:
- 骨组织工程 (BTE) 旨在使用细胞,支架和信号分子来修复骨.
- 酸盐 (CS) 是BTE支架的一个有前途的天然聚合物,因为它具有生物相容性和生物降解性.
- CS支架通常需要交叉连接来克服固有的机械弱点.
研究的目的:
- 审查物理和化学交叉连接剂在增强BTE的基托基支架中的作用.
- 讨论交叉连接如何影响脚手架的特性和生物功能.
- 突出了解骨再生的交叉连接器化学的重要性.
主要方法:
- 关于CS支架的物理交叉连接 (紫外线照射,冷解) 和化学交叉连接 (甲) 的文献综述.
- 对交叉连接对脚手架物理化学性质,机械强度和生物相容性影响的分析.
- 评估交叉连接对生物活性和分子受控释放的影响.
主要成果:
- 物理交叉连接提供生物相容性,但机械强度有限.
- 化学交叉连接显著提高机械强度,但可能会引起细胞毒性问题.
- 交叉连接增强了CS脚手架的稳定性,机械性能,生物相容性和骨再生的生物功能.
结论:
- 交叉连接对于优化骨组织工程中的基托基支架至关重要.
- 物理和化学交联方法都有明显的优势和局限性.
- 进一步了解交叉连接器化学对于开发先进的骨再生疗法至关重要.
更多相关视频
12:22Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
11.8K
10:49Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
Published on: August 21, 2021
4.4K
相关概念视频
01:23Bone as Supporting Connective Tissue
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
01:27Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...