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来自可再生香伪体的化微晶纤维素:物理化学和功能分析

Pratap Kalita¹, Probin Kumar Roy², Nirupam Das³

¹Pratiksha Institute of Pharmaceutical Sciences, Guwahati, Assam 781026, India.

International journal of biological macromolecules

|November 15, 2024

概括

来自香伪茎的微晶纤维素 (MCC) 被化以改善其性能. 这一过程提高了流动性,紧性和可分片性,显示了可持续药物辅助剂的潜力.

科学领域:

材料科学材料科学材料科学
制药技术制药技术制药技术

背景情况:

微晶纤维素 (MCC) 是一种来自纤维素的常见制药辅助剂.
它的纤维性质可能导致流量和紧缩性差,往往需要共同加工.
目前正在探索MCC的可持续来源,以提高其功能.

研究的目的:

从Musa balbisiana的伪树干中分离和描述MCC.
研究化对Musa MCC.物理化学和制药性质的影响.
评估化Musa MCC作为可持续的制药辅助剂的潜力.

主要方法:

通过酸水解从Musa balbisiana pseudostem中分离MCC.
使用2%的二氧化通过同质化,过和干燥来化MCC.
使用FTIR,SEM-EDS,XRD,TGA-DTG和制药功能测试 (包装,巩固,可压缩性,可紧缩性,可平板性) 的表征.

主要成果:

化降低了MCC的结晶性,但提高了热稳定性.
化通过减少内部摩擦,提高了MCC的凝聚力和流动特性.
化减少了塑料变形,但显著提高了紧缩性和可平板性.
与商业MCC相比,化Musa MCC表现出优越的药物功能特性.

结论:

莫萨巴尔比西安娜的伪茎是MCC的可行和可持续的来源.
化是一种有效的方法来增强MCC的功能性质,特别是紧缩性和可平板性.
化Musa MCC作为制药制造的高性能,可持续的辅助剂具有前景.

关键词:

压缩是压缩的方法.压缩压缩压缩压缩辅助物质辅助物质辅助物质微晶纤维素的微晶纤维素.化过程中的化.可持续发展可持续性可持续性

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