转移性膀癌的指导方针与现实数据:一项关于第一线化疗治疗模式的基于人口的研究
Ellis Slotman1, Anke Richters2, Heidi P Fransen3
1Netherlands Comprehensive Cancer Organisation, Department of Research and Development, Utrecht, The Netherlands; University of Twente, Technical Medical Centre, Department of Health Technology and Services Research, Enschede, The Netherlands.
Urologic oncology
|November 15, 2024
概括
对于接受化疗的转移性膀癌 (mBC) 患者,大多数患者没有完成完整的推治疗过程. 治疗调整是常见的,突出了遵守指南的挑战.
科学领域:
- 在瘤学瘤学.
- 临床药房 临床药房
- 癌症研究 癌症研究
背景情况:
- 息化疗是转移性膀癌 (mBC) 的首要治疗方法.
- 关于化疗周期和mBC调整的现实数据有限.
研究的目的:
- 分析在mBC中第一线化疗的现实世界治疗模式.
- 确定影响治疗完成的因素和调整原因.
主要方法:
- 在荷兰 (2016-2021) 接受初始化疗的mBC患者的基于人口的研究.
- 从荷兰癌症登记处收集的关于患者,瘤和治疗特征的数据.
- 描述性分析和后勤回归以评估治疗完成和相关因素.
主要成果:
- 在684名患者中,有35%的患者没有接受全部4-6次化疗周期.
- 男性性别和良好表现状况与完成治疗有关.
- 接受全方位治疗的半数患者仍有调整,主要是减少副作用的剂量.
结论:
- 在mBC中遵守推的化疗周期是具有挑战性的.
- 治疗调整是频繁的,影响患者的结果.
- 整合治疗修改的现实数据对于共享决策和指导方针改进至关重要.
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