影响癌症免疫治疗结果的因素:萨科佩尼亚和系统性炎症
Enes Ucgul1, Deniz Can Guven2, Aybala Nur Ucgul3
1Division of Endocrinology and Metabolism, Etlik City Hospital, Ankara, Turkey.
Cancer control : journal of the Moffitt Cancer Center
|November 15, 2024
概括
肌肉质量损失的萨尔科佩尼亚显著恶化了接受免疫治疗的癌症患者的无进展生存率. 监测和预防肉类可能会改善整体生存率和无进展生存结果.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 老年医学 老年医学
背景情况:
- 免疫疗法对转移性癌症有希望,但患者的脆弱性和免疫状况会影响结果.
- 标志着肌肉质量损失和炎症的萨尔科佩尼亚可能会对免疫疗法反应产生负面影响.
- 东方合作瘤组绩效状况 (ECOG PS) 是影响治疗疗效的另一个因素.
研究的目的:
- 为了研究萨科佩尼亚对免疫疗法反应的影响.
- 评估系统性炎症标志物在预测治疗结果中的作用.
- 评估萨尔科佩尼亚,炎症和ECOGPS对患者生存的综合影响.
主要方法:
- 对接受免疫检查点抑制剂的100名患者 (2015-2021) 的回顾性分析.
- 计算机断层扫描 (CT) 扫描用于诊断肉症,具有特定性别值.
- 系统性炎症通过C反应蛋白 (CRP),红细胞沉积率,中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),专蛋白和乳酸脱酶 (LDH) 来评估.
主要成果:
- 麻症是不良无进展生存 (PFS) 的显著预测因素 (HR,2.33;P < 0.001).
- 低蛋白血症成为整体存活 (OS) 的重要预测因素 (HR,2.10;P = 0.008).
结论:
- 密切监测和预防肉类可能会改善OS和PFS.
- 结合这些因素的复合模型可以提高免疫治疗反应的预测.
- 建议进行进一步的前性研究以验证.
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