在具有炎症性肠病的社会脆弱患者中,接种疫苗的差异
Jessica L Sheehan1,2, Ariel A Jordan3, Kira L Newman3
1Department of Internal Medicine, Division of Gastroenterology and Hepatology, Michigan Medicine, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA. jesheeha@med.umich.edu.
Digestive diseases and sciences
|November 15, 2024
概括
社会脆弱性影响了炎症性肠病 (IBD) 患者的疫苗坚持. 更高的社会脆弱性与较低的流感疫苗接种率有关,COVID-19,肺炎球菌肺炎和疹.
科学领域:
- 公共卫生 公共卫生
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 健康的社会决定因素 (SDOH) 显著影响健康差异,包括疫苗接种率.
- 患有炎症性肠病 (IBD) 的患者面临更高的感染风险,但他们的SDOH和疫苗接种状况仍未得到充分研究.
研究的目的:
- 利用CDC的社会脆弱性指数 (SVI) 调查SDOH与IBD患者的指导方针推接种疫苗之间的关联.
- 确定影响该脆弱人群接种疫苗的特定SVI子主题.
主要方法:
- 一个单一中心的7036名IBD患者的回顾性队列研究.
- 地理编码患者地址到人口普查区,并链接到SVI数据和子主题 (社会经济地位,家庭组成,少数群体地位,住房/交通).
- 进行了多变量后勤回归分析,以评估SVI与流感,COVID-19,肺炎球菌肺炎和疹疫苗接种状态之间的关系.
主要成果:
- 疫苗接种率各不相同:流感 (57%),COVID-19 (65%),肺炎球菌性肺炎 (58%) 和疹 (11%).
- 更高的社会脆弱性与接受所有研究疫苗的几率较低显著相关 (ORs从0.39到0.73不等,所有p<0.012).
- 社会经济地位,家庭组成和少数群体地位成为与疫苗接种差异相关的关键SVI子主题.
结论:
- 增加的社会脆弱性与IBD患者所有疫苗类型的疫苗接种率降低相关.
- 解决这些发现的疫苗接种差异对于预防感染和确保社会脆弱的IBD患者获得公平,高质量的护理至关重要.
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