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Updated: Jun 7, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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在KLHDCX家族E3泛素酶中C-降解子选择性的结构基础

Daniel C Scott1, Sagar Chittori1, Nicholas Purser2

  • 1Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Nature communications
|November 15, 2024
PubMed
概括

研究人员发现了特定的E3链酶如何识别蛋白质降解信号 (C-degrons). 他们发现,在KLHDCX家族的Cullin-RING连接酶 (CRL) 中,不同的结构机制决定了基质结合和无处不在的特异性.

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