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精神药物诱导的体重增加和端粒长度:来自一年的纵向研究和大量基于人口的队列研究的结果
Marianna Piras1, Jue Lin2, Marie Catherine Sadler3,4,5
1Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Lausanne, Prilly, Switzerland. Marianna.piras@chuv.ch.
Translational psychiatry
|November 15, 2024
概括
诱导体重的精神药物加速端粒缩短,特别是在基线体重低且体重显著增加的患者中. 这一过程与炎症和体重指数 (BMI) 的增加有关.
科学领域:
- 遗传学和衰老研究研究
- 精神药理学和代谢健康
背景情况:
- 心理药物的体重增加是与年龄有关的疾病的危险因素,包括心血管疾病.
- 心血管疾病与炎症和端粒长度缩短有关,这是细胞衰老的关键指标.
研究的目的:
- 为了评估体重诱导性精神药物治疗一年后的端粒长度轨迹.
- 评估体重变化和高灵敏性C反应蛋白 (CRP) 对端粒长度的影响.
主要方法:
- 在200名接受体重诱导性精神药物治疗的患者进行了长度研究.
- 在一年内分析端粒长度,体重指数 (BMI) 和CRP水平.
- 使用UKBiobank数据建立因果关系的孟德尔随机化.
主要成果:
- 观察到端粒缩短的中位数为-41.2 bp,与一般人群相比.
- 增加的BMI显著加快了端粒缩短,特别是在基线体重较低和体重明显增加 (≥7%) 的患者中.
- 体重增加与较高的CRP水平相关,而较高的CRP水平与加速的端粒缩短有关.
结论:
- 端粒缩短与体重增加和心理治疗一年后CRP水平增加有关.
- 体重指数 (BMI) 的增加显著增加了体重诱导性精神药物患者的端粒缩短.
- 研究结果强调了某些精神药物治疗的加快衰老影响,其介于体重增加和炎症.
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