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Updated: Jun 7, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
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碳 - - 切换效应在 - 类固醇中心的enantioselective构造中的 - 类固醇中心来自silicacyclohexadienones

Yu Yan1,2, Qi Wei3, Zhishan Su4

  • 1Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant, College of Chemistry and Chemical Engineering, Chengdu University, Chengdu, China.

Nature communications
|November 15, 2024
PubMed
概括

碳 - - 切换策略显著改变化学反应. 在分子中用取代碳反转了酶选择性并改变了反应性,为功能分子的发展提供了新的途径.

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Stereochemical Effects of Enolization

The chiral α-carbon of the carbonyl compound is the stereocenter of the molecule. As shown in the figure below, when such a carbonyl compound undergoes racemization under an acidic or basic condition, an achiral enol is formed.
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Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
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