血清佐努林和结直肠癌的风险
Mirko Marino1, Silvia Mignozzi2, Karin B Michels3
1Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, Italy.
Scientific reports
|November 15, 2024
概括
肠道屏障功能障碍的标志物 - - ゾ努林的升高与增加结直肠癌 (CRC) 风险有关. 较高的佐努林和细菌DNA水平显著提高了CRC风险,这表明它们在CRC发展中的作用.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 肠道透性与结直肠癌 (CRC) 病原发生有关.
- 佐努林调节肠道屏障功能,可能表明CRC中的细菌转位.
研究的目的:
- 为了研究血清中佐努林水平与CRC风险之间的关联.
- 探索 zonulin 和细菌 16S rRNA 基因拷贝在 CRC 发育中的联合作用.
主要方法:
- 一项病例控制研究涉及77例CRC病例,72例肠腺瘤患者和76例健康对照.
- 使用ELISA和通过PCR通过血液16SrRNA基因拷贝量化血清佐努林.
- 对相关共变量进行调整的后勤回归模型.
主要成果:
- 在较高的佐努林水平和CRC风险之间发现了积极的关联 (OR 2.36).
- 在结肠癌和直肠癌中也观察到类似的关联.
- 增加佐努林和16S rRNA基因拷贝的水平显著增加了结肠癌的风险 (OR 4.55).
结论:
- 在CRC患者中,循环素水平较高,支持肠道屏障功能障碍与结直肠癌发生过程中的细菌转移之间的联系.
- 佐努林可以作为一种有价值的生物标志物用于CRC诊断,可能与细菌标志物结合使用.
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