阶段角是维持血液透析患者中蛋白质能量浪费和心血管风险的有用预测指标
Yun Wang1, Yu Chen2, Liqin Zhang1
1Department of Nephrology, The Affiliated Huaian No.1, People's Hospital of Nanjing Medical University, Huaian, Jiangsu, China.
Scientific reports
|November 15, 2024
概括
通过生物电阻分析 (BIA) 测量的相角 (PA) 有效预测维持血液透析 (MHD) 患者的蛋白质能量浪费 (PEW) 和心血管 (CV) 风险. 将PA与ASMI,BCM和MAC结合起来,可以提高MHD患者的PEW预测准确度.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 营养科学 营养科学
- 心脏病学 心脏病学
背景情况:
- 蛋白质能量浪费 (PEW) 显著增加了维持血液透析 (MHD) 患者的死亡率.
- 心血管疾病 (CVD) 是透析患者的主要死亡原因,PEW加剧了这种风险.
- 阶段角 (PA) 显示了作为MHD患者营养状况和预后的客观指标的潜力.
研究的目的:
- 用生物电阻分析 (BIA) 来评估PEW和MHD患者心血管 (CV) 风险的相角 (PA) 的预测值.
- 确定用于预测MHD患者PEW的关键身体组成参数.
主要方法:
- 追溯观察性研究涉及161名成年维护血液透析患者.
- 使用LASSO逻辑回归来确定PEW的预测参数.
- 使用基于日本透析结果和实践模式研究 (J-DOPPS) 的得分来评估心血管风险.
主要成果:
- 阶段角 (PA),尾骨肌肉质量指数 (ASMI),体细胞质量 (BCM) 和中臂周长 (MAC) 显示PEW的预测值,特别是在男性患者中.
- 结合PA,ASMI,BCM和MAC的组合模型显示PEW的预测准确性高于单个参数 (男性AUC为0.877,女性为0.76).
- 较低的PA显著与更高的PEW发病率 (P < 0.001) 和心血管风险得分增加有关.
结论:
- 通过生物电阻分析 (BIA) 测量的相角 (PA) 是预测PEW和MHD患者心血管事件风险的宝贵工具.
- PA,ASMI,BCM和MAC的组合为在维护血液透析患者中识别PEW提供了高诊断效率.
- 这些发现强调了身体组成评估对于管理MHD人群的营养状况和心血管风险的重要性.
相关概念视频
Dialysis
269
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
269
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
60
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
60
Renal Failure: Dose Adjustments
67
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
67
Factors Affecting Renal Clearance: Renal Impairment
57
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
57


