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状细胞缩病的患病率和预测因素一个单一中心的经验

Khaled Elzorkany^1,2, Mortadah Alsalman³, Muthana AlSahlawi³

¹Internal Medicine Department, College of Medicine, King Faisal University, Al- Ahsa, Saudi Arabia. kelzorkany@kfu.edu.sa.

Scientific reports

|November 15, 2024

概括

状细胞病 (SCN) 影响了沙特阿拉伯超过四分之一的状细胞病 (SCD) 患者. 高龄和低血红蛋白是SCD患者损伤的关键预测因素.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
血液学血液学血液学
遗传学是一个遗传学.

背景情况:

状细胞疾病 (SCD) 是沙特阿拉伯普遍存在的一种单一性疾病.
SCD显著增加了器官损伤的风险,特别是影响脏.

研究的目的:

确定沙特人口中状细胞病 (SCN) 的患病率和预测因子.
评估成人SCD患者的功能和蛋白尿.

主要方法:

一项追溯性研究,从2023年4月到10月,涉及343名成人SCD患者.
使用CKD-EPI方程测量斑点蛋白与肌素的比率并估计膜过率 (GFR).
根据KIDGO指南诊断慢性病 (CKD).

主要成果:

在SCD患者中,CKD被诊断为27.1%.
蛋白尿症在26.5%的患者中存在.
对SCN的独立风险因素包括年龄 (OR 1.035) 和低血红蛋白水平 (OR 0.721).
患有CKD的患者年龄较大,糖尿病 (DM) 和高血压 (HTN) 的发病率较高.

结论:

状细胞病是SCD患者的常见并发症,通常在第三个十年内无症状发展.
年龄和低血红蛋白水平是SCN的重要预测因素.
像DM和HTN这样的同时存在的疾病加剧了SCD中病的风险.

关键词:

在CKD中,它是最重要的.氧尿素可以在水中形成.状细胞疾病;状细胞脏病.

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