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尼古丁胺胺 рибоoside对COPD呼吸道炎症的影响:一种随机的,安慰剂控制的试验
Kristoffer L Norheim1,2,3, Michael Ben Ezra1, Indra Heckenbach4
1Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
在慢性阻塞性肺病 (COPD) 患者中,尼古丁胺胺 рибоoside (NR) 显著降低了呼吸道炎症 (IL-8). 治疗结束后,COPD症状的改善仍然存在,这表明NRNR可能存在.
科学领域:
- 肺部医学 肺部医学
- 衰老研究研究 衰老研究
- 代谢健康 代谢健康
背景情况:
- 慢性阻塞性肺病 (COPD) 是与衰老和吸烟有关的主要死亡原因.
- DNA损伤和NAD+水平的下降与衰老和COPD病变产生有关.
- 尼古丁胺胺氨基二核酸 (NAD+) 是细胞功能和修复的关键代谢物.
研究的目的:
- 为了研究尼古丁胺基核酸 (NR) 作为稳定性COPD的干预措施的疗效.
- 评估NR对呼吸道炎症和COPD患者的NAD+水平的影响.
- 探索NR对COPD基因完整性和表观遗传衰老的影响.
主要方法:
- 一个随机,双盲,安慰剂控制的临床试验,涉及40名稳定的COPD患者.
- 患者接受NR或安慰剂6周,并进行后续评估.
- 主要结局:唾液中介质素-8 (IL-8) 的变化;次要结局:血液中的NAD+和血IL-6水平.
主要成果:
- 在6周后,NR治疗显著降低了液IL-8水平的52.6% (P=0.030),这种效果在12周后续持续 (-63.7%,P=0.034).
- NR补充剂使全血NAD+水平增加了一倍以上.
- 探索性分析表明,NR可能会提高基因组完整性通路的调节,并减少COPD气道的表观遗传衰老.
结论:
- 尼古丁胺胺 рибоoside (NR) 有效地降低了COPD患者的呼吸道炎症.
- 补充NR可以增加NAD+水平,并显示出对基因组完整性和COPD衰老途径的潜在益处.
- 需要进一步的研究来证实NR在COPD治疗中的治疗潜力.
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