同等氨酸水平与心血管疾病死亡率之间的关联:基于NHANES数据库的队列研究
Donghao Liu1,2, Chuangsen Fang3,2, Jia Wang1,4
1Department of Cardiology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
高水平的同类氨酸 (Hcy) 会增加心血管疾病 (CVD) 和所有原因的死亡风险,在患有现有的心血管疾病的患者. 这种风险即使在Hcy度低于以前所认为的水平,也很明显.
科学领域:
- 心脏病学 心脏病学
- 临床研究 临床研究
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 构成了全球重大健康挑战,经典风险因素仅解释了半数病例.
- 同类氨酸 (Hcy) 正被调查为潜在的CVD风险贡献者,促使对其作用进行研究.
研究的目的:
- 调查已确定的心血管疾病 (CVD) 患者的同类氨酸 (Hcy) 水平和死亡率之间的关联.
- 为了确定Hcy是否在低于常规值的度下构成死亡风险.
主要方法:
- 一项前性队列研究分析了来自NHANES 1999-2006的1739名美国心血管疾病患者 (年龄≥30) 的数据.
- 考克斯的比例危险回归和受限制的立方线被用来评估Hcy水平和死亡率之间的关系,调整为共变量.
主要成果:
- 升高的Hcy水平与增加的全因死亡率 (P趋势<0.0001) 和心血管疾病死亡率 (P趋势=0.0086) 显著相关.
- 即使在Hcy水平低于常规值时,也观察到这种风险,所有原因的死亡率为14.5μmol/L,心血管疾病死亡率为14.6μmol/L.
- 亚组分析表明与年龄,血清维生素B12和吸烟状况的相互作用.
结论:
- 较高的同类半氨酸 (Hcy) 水平与现有心血管疾病患者的全因和心血管疾病 (CVD) 死亡率的增加有关.
- Hcy对健康结果的有害影响在比以前理解的更低度时显而易见.
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